| Buffalo to Orangevale (California) | 2,211.80 mi (3,559.55 km) |
| Buffalo to Orchards (Washington) | 2,141.87 mi (3,447.01 km) |
| Buffalo to Orcutt (California) | 2,279.15 mi (3,667.94 km) |
| Buffalo to Oregon (Ohio) | 249.67 mi (401.80 km) |
| Buffalo to Oregon (Wisconsin) | 533.03 mi (857.83 km) |
| Buffalo to Oregon City (Oregon) | 2,149.43 mi (3,459.17 km) |
| Buffalo to Orem (Utah) | 1,695.98 mi (2,729.42 km) |
| Buffalo to Orinda (California) | 2,280.89 mi (3,670.74 km) |
| Buffalo to Orland Park (Illinois) | 469.29 mi (755.25 km) |
| Buffalo to Orlando (Florida) | 1,006.24 mi (1,619.39 km) |
| Buffalo to Ormond Beach (Florida) | 948.17 mi (1,525.93 km) |
| Buffalo to Oro Valley (Arizona) | 1,886.20 mi (3,035.54 km) |
| Buffalo to Oroville (California) | 2,209.07 mi (3,555.15 km) |
| Buffalo to Oshkosh (Wisconsin) | 492.93 mi (793.30 km) |
| Buffalo to Oskaloosa (Iowa) | 714.93 mi (1,150.56 km) |
