| Buffalo to Olympia Heights (Florida) | 1,189.86 mi (1,914.89 km) |
| Buffalo to Omaha (Nebraska) | 887.88 mi (1,428.91 km) |
| Buffalo to On Top of the World Designated Place (Florida) | 972.15 mi (1,564.52 km) |
| Buffalo to Onalaska (Wisconsin) | 623.62 mi (1,003.62 km) |
| Buffalo to Oneida (New York) | 161.49 mi (259.89 km) |
| Buffalo to Oneonta (New York) | 194.56 mi (313.11 km) |
| Buffalo to Ontario (California) | 2,163.08 mi (3,481.14 km) |
| Buffalo to Ontario (Oregon) | 1,896.46 mi (3,052.06 km) |
| Buffalo to Opa-locka (Florida) | 1,177.42 mi (1,894.87 km) |
| Buffalo to Opelika (Alabama) | 791.66 mi (1,274.05 km) |
| Buffalo to Opelousas (Louisiana) | 1,123.40 mi (1,807.93 km) |
| Buffalo to Orange (California) | 2,181.66 mi (3,511.04 km) |
| Buffalo to Orange (Texas) | 1,206.83 mi (1,942.21 km) |
| Buffalo to Orange City (Florida) | 974.51 mi (1,568.32 km) |
| Buffalo to Orangeburg (South Carolina) | 659.21 mi (1,060.90 km) |
