| Buffalo to Indianola (Iowa) | 760.52 mi (1,223.94 km) |
| Buffalo to Indio (California) | 2,103.82 mi (3,385.78 km) |
| Buffalo to Inglewood (California) | 2,203.07 mi (3,545.50 km) |
| Buffalo to Inkster (Michigan) | 230.98 mi (371.72 km) |
| Buffalo to Inver Grove Heights (Minnesota) | 719.31 mi (1,157.61 km) |
| Buffalo to Inwood (New York) | 306.27 mi (492.89 km) |
| Buffalo to Iona (Florida) | 1,145.63 mi (1,843.71 km) |
| Buffalo to Ionia (Michigan) | 314.79 mi (506.60 km) |
| Buffalo to Iowa City (Iowa) | 653.34 mi (1,051.45 km) |
| Buffalo to Irmo (South Carolina) | 621.05 mi (999.48 km) |
| Buffalo to Irondale (Alabama) | 772.40 mi (1,243.06 km) |
| Buffalo to Ironton (Ohio) | 362.34 mi (583.13 km) |
| Buffalo to Irvine (California) | 2,183.40 mi (3,513.84 km) |
| Buffalo to Irving (Texas) | 1,203.36 mi (1,936.61 km) |
| Buffalo to Isabela (Puerto Rico) | 1,822.23 mi (2,932.59 km) |
