| Buffalo to Enumclaw (Washington) | 2,099.40 mi (3,378.65 km) |
| Buffalo to Ephrata (Pennsylvania) | 233.14 mi (375.20 km) |
| Buffalo to Erie (Colorado) | 1,364.63 mi (2,196.17 km) |
| Buffalo to Erie (Pennsylvania) | 82.66 mi (133.03 km) |
| Buffalo to Erlanger (Kentucky) | 402.20 mi (647.28 km) |
| Buffalo to Escanaba (Michigan) | 452.03 mi (727.47 km) |
| Buffalo to Escondido (California) | 2,166.17 mi (3,486.11 km) |
| Buffalo to Española (New Mexico) | 1,520.54 mi (2,447.07 km) |
| Buffalo to Essex (Maryland) | 278.40 mi (448.04 km) |
| Buffalo to Essex Junction (Vermont) | 306.69 mi (493.57 km) |
| Buffalo to Estelle (Louisiana) | 1,095.86 mi (1,763.62 km) |
| Buffalo to Estero (Florida) | 1,150.30 mi (1,851.23 km) |
| Buffalo to Euclid (Ohio) | 163.88 mi (263.75 km) |
| Buffalo to Eufaula (Alabama) | 833.86 mi (1,341.97 km) |
| Buffalo to Eugene (Oregon) | 2,193.88 mi (3,530.71 km) |
