| Buffalo to Emeryville (California) | 2,287.77 mi (3,681.82 km) |
| Buffalo to Emmaus (Pennsylvania) | 237.88 mi (382.82 km) |
| Buffalo to Emporia (Kansas) | 958.75 mi (1,542.96 km) |
| Buffalo to Encinitas (California) | 2,178.58 mi (3,506.09 km) |
| Buffalo to Endicott (New York) | 152.33 mi (245.16 km) |
| Buffalo to Endwell (New York) | 153.81 mi (247.53 km) |
| Buffalo to Englewood (Colorado) | 1,370.47 mi (2,205.56 km) |
| Buffalo to Englewood (Florida) | 1,118.13 mi (1,799.45 km) |
| Buffalo to Englewood (New Jersey) | 286.55 mi (461.16 km) |
| Buffalo to Englewood (Ohio) | 352.17 mi (566.77 km) |
| Buffalo to Enid (Oklahoma) | 1,103.65 mi (1,776.16 km) |
| Buffalo to Ennis (Texas) | 1,212.97 mi (1,952.08 km) |
| Buffalo to Ensley (Florida) | 972.89 mi (1,565.71 km) |
| Buffalo to Enterprise (Alabama) | 886.98 mi (1,427.46 km) |
| Buffalo to Enterprise (Nevada) | 1,981.79 mi (3,189.39 km) |
