| Buffalo to Desert Hot Springs (California) | 2,112.12 mi (3,399.13 km) |
| Buffalo to DeSoto (Texas) | 1,210.35 mi (1,947.87 km) |
| Buffalo to Destin (Florida) | 960.86 mi (1,546.35 km) |
| Buffalo to Destrehan (Louisiana) | 1,097.36 mi (1,766.02 km) |
| Buffalo to Detroit (Michigan) | 219.11 mi (352.63 km) |
| Buffalo to Diamond Bar (California) | 2,174.98 mi (3,500.30 km) |
| Buffalo to Diamond Springs (California) | 2,192.52 mi (3,528.53 km) |
| Buffalo to Dickinson (North Dakota) | 1,198.81 mi (1,929.31 km) |
| Buffalo to Dickinson (Texas) | 1,291.83 mi (2,079.00 km) |
| Buffalo to Dickson (Tennessee) | 654.72 mi (1,053.66 km) |
| Buffalo to Difficult Run (Virginia) | 287.28 mi (462.34 km) |
| Buffalo to Dinuba (California) | 2,177.36 mi (3,504.13 km) |
| Buffalo to Discovery Bay (California) | 2,251.02 mi (3,622.67 km) |
| Buffalo to Dix Hills (New York) | 318.45 mi (512.50 km) |
| Buffalo to Dixon (California) | 2,248.28 mi (3,618.26 km) |
