| Brookings to Southern Pines (North Carolina) | 1,113.82 mi (1,792.52 km) |
| Brookings to Southfield (Michigan) | 689.89 mi (1,110.27 km) |
| Brookings to Southgate (Michigan) | 697.72 mi (1,122.87 km) |
| Brookings to Southlake (Texas) | 784.29 mi (1,262.20 km) |
| Brookings to Spanaway (Washington) | 1,246.37 mi (2,005.84 km) |
| Brookings to Spanish Fork (Utah) | 812.11 mi (1,306.96 km) |
| Brookings to Spanish Lake (Missouri) | 510.39 mi (821.39 km) |
| Brookings to Spanish Springs (Nevada) | 1,213.93 mi (1,953.64 km) |
| Brookings to Sparks (Nevada) | 1,218.46 mi (1,960.92 km) |
| Brookings to Spartanburg (South Carolina) | 1,018.76 mi (1,639.53 km) |
| Brookings to Spearfish (South Dakota) | 347.18 mi (558.73 km) |
| Brookings to Speedway (Indiana) | 623.27 mi (1,003.06 km) |
| Brookings to Spencer (Iowa) | 114.09 mi (183.61 km) |
| Brookings to Spokane (Washington) | 1,014.86 mi (1,633.25 km) |
| Brookings to Spokane Valley (Washington) | 1,005.64 mi (1,618.42 km) |
