| Boston to Southern Pines (North Carolina) | 3,909.21 mi (6,291.27 km) |
| Boston to Southfield (Michigan) | 3,713.27 mi (5,975.93 km) |
| Boston to Southgate (Michigan) | 3,723.81 mi (5,992.89 km) |
| Boston to Southlake (Texas) | 4,711.26 mi (7,582.04 km) |
| Boston to Spanaway (Washington) | 4,738.63 mi (7,626.09 km) |
| Boston to Spanish Fork (Utah) | 4,825.37 mi (7,765.68 km) |
| Boston to Spanish Lake (Missouri) | 4,151.97 mi (6,681.96 km) |
| Boston to Spanish Springs (Nevada) | 5,094.21 mi (8,198.34 km) |
| Boston to Sparks (Nevada) | 5,100.39 mi (8,208.28 km) |
| Boston to Spartanburg (South Carolina) | 4,021.94 mi (6,472.69 km) |
| Boston to Spearfish (South Dakota) | 4,339.21 mi (6,983.28 km) |
| Boston to Speedway (Indiana) | 3,953.49 mi (6,362.53 km) |
| Boston to Spencer (Iowa) | 4,115.01 mi (6,622.47 km) |
| Boston to Spokane (Washington) | 4,574.22 mi (7,361.50 km) |
| Boston to Spokane Valley (Washington) | 4,569.08 mi (7,353.22 km) |
