| Boone to Southern Pines (North Carolina) | 145.16 mi (233.61 km) |
| Boone to Southfield (Michigan) | 441.17 mi (709.99 km) |
| Boone to Southgate (Michigan) | 422.21 mi (679.48 km) |
| Boone to Southlake (Texas) | 907.94 mi (1,461.19 km) |
| Boone to Spanaway (Washington) | 2,205.34 mi (3,549.15 km) |
| Boone to Spanish Fork (Utah) | 1,642.51 mi (2,643.37 km) |
| Boone to Spanish Lake (Missouri) | 500.64 mi (805.70 km) |
| Boone to Spanish Springs (Nevada) | 2,069.09 mi (3,329.88 km) |
| Boone to Sparks (Nevada) | 2,072.14 mi (3,334.79 km) |
| Boone to Spartanburg (South Carolina) | 88.73 mi (142.79 km) |
| Boone to Spearfish (South Dakota) | 1,293.35 mi (2,081.44 km) |
| Boone to Speedway (Indiana) | 351.30 mi (565.37 km) |
| Boone to Spencer (Iowa) | 860.86 mi (1,385.41 km) |
| Boone to Spokane (Washington) | 1,979.19 mi (3,185.20 km) |
| Boone to Spokane Valley (Washington) | 1,970.06 mi (3,170.50 km) |
