| Bluffton to Southern Pines (North Carolina) | 223.78 mi (360.14 km) |
| Bluffton to Southfield (Michigan) | 720.47 mi (1,159.48 km) |
| Bluffton to Southgate (Michigan) | 701.50 mi (1,128.95 km) |
| Bluffton to Southlake (Texas) | 944.68 mi (1,520.31 km) |
| Bluffton to Spanaway (Washington) | 2,399.16 mi (3,861.08 km) |
| Bluffton to Spanish Fork (Utah) | 1,787.50 mi (2,876.71 km) |
| Bluffton to Spanish Lake (Missouri) | 691.13 mi (1,112.27 km) |
| Bluffton to Spanish Springs (Nevada) | 2,209.23 mi (3,555.41 km) |
| Bluffton to Sparks (Nevada) | 2,211.60 mi (3,559.23 km) |
| Bluffton to Spartanburg (South Carolina) | 197.15 mi (317.28 km) |
| Bluffton to Spearfish (South Dakota) | 1,494.02 mi (2,404.40 km) |
| Bluffton to Speedway (Indiana) | 601.88 mi (968.63 km) |
| Bluffton to Spencer (Iowa) | 1,081.28 mi (1,740.15 km) |
| Bluffton to Spokane (Washington) | 2,180.67 mi (3,509.45 km) |
| Bluffton to Spokane Valley (Washington) | 2,171.71 mi (3,495.03 km) |
