| Big Spring to Enumclaw (Washington) | 1,493.60 mi (2,403.72 km) |
| Big Spring to Ephrata (Pennsylvania) | 1,506.83 mi (2,425.00 km) |
| Big Spring to Erie (Colorado) | 574.33 mi (924.29 km) |
| Big Spring to Erie (Pennsylvania) | 1,356.17 mi (2,182.55 km) |
| Big Spring to Erlanger (Kentucky) | 1,055.57 mi (1,698.77 km) |
| Big Spring to Escanaba (Michigan) | 1,207.82 mi (1,943.80 km) |
| Big Spring to Escondido (California) | 907.99 mi (1,461.27 km) |
| Big Spring to Española (New Mexico) | 369.47 mi (594.60 km) |
| Big Spring to Essex (Maryland) | 1,480.08 mi (2,381.96 km) |
| Big Spring to Essex Junction (Vermont) | 1,741.60 mi (2,802.84 km) |
| Big Spring to Estelle (Louisiana) | 693.18 mi (1,115.56 km) |
| Big Spring to Estero (Florida) | 1,249.57 mi (2,010.98 km) |
| Big Spring to Euclid (Ohio) | 1,273.44 mi (2,049.41 km) |
| Big Spring to Eufaula (Alabama) | 955.38 mi (1,537.54 km) |
| Big Spring to Eugene (Oregon) | 1,424.30 mi (2,292.20 km) |
