| Big Spring to Emeryville (California) | 1,236.21 mi (1,989.49 km) |
| Big Spring to Emmaus (Pennsylvania) | 1,547.50 mi (2,490.46 km) |
| Big Spring to Emporia (Kansas) | 519.58 mi (836.19 km) |
| Big Spring to Encinitas (California) | 918.97 mi (1,478.94 km) |
| Big Spring to Endicott (New York) | 1,548.28 mi (2,491.72 km) |
| Big Spring to Endwell (New York) | 1,550.76 mi (2,495.71 km) |
| Big Spring to Englewood (Colorado) | 548.16 mi (882.18 km) |
| Big Spring to Englewood (Florida) | 1,203.29 mi (1,936.51 km) |
| Big Spring to Englewood (New Jersey) | 1,630.83 mi (2,624.56 km) |
| Big Spring to Englewood (Ohio) | 1,091.75 mi (1,757.00 km) |
| Big Spring to Enid (Oklahoma) | 353.97 mi (569.65 km) |
| Big Spring to Ennis (Texas) | 283.06 mi (455.55 km) |
| Big Spring to Ensley (Florida) | 845.66 mi (1,360.96 km) |
| Big Spring to Enterprise (Alabama) | 919.55 mi (1,479.86 km) |
| Big Spring to Enterprise (Nevada) | 827.48 mi (1,331.70 km) |
