| Big Lake to Southern Pines (North Carolina) | 1,028.24 mi (1,654.79 km) |
| Big Lake to Southfield (Michigan) | 557.58 mi (897.35 km) |
| Big Lake to Southgate (Michigan) | 568.11 mi (914.28 km) |
| Big Lake to Southlake (Texas) | 874.90 mi (1,408.02 km) |
| Big Lake to Spanaway (Washington) | 1,368.67 mi (2,202.66 km) |
| Big Lake to Spanish Fork (Utah) | 975.04 mi (1,569.17 km) |
| Big Lake to Spanish Lake (Missouri) | 487.63 mi (784.76 km) |
| Big Lake to Spanish Springs (Nevada) | 1,371.07 mi (2,206.52 km) |
| Big Lake to Sparks (Nevada) | 1,375.77 mi (2,214.09 km) |
| Big Lake to Spartanburg (South Carolina) | 949.63 mi (1,528.29 km) |
| Big Lake to Spearfish (South Dakota) | 495.97 mi (798.18 km) |
| Big Lake to Speedway (Indiana) | 540.29 mi (869.51 km) |
| Big Lake to Spencer (Iowa) | 166.93 mi (268.65 km) |
| Big Lake to Spokane (Washington) | 1,133.46 mi (1,824.13 km) |
| Big Lake to Spokane Valley (Washington) | 1,124.23 mi (1,809.28 km) |
