| Big Lake to Scottsboro (Alabama) | 842.99 mi (1,356.66 km) |
| Big Lake to Scottsdale (Arizona) | 1,252.40 mi (2,015.54 km) |
| Big Lake to Scranton (Pennsylvania) | 945.51 mi (1,521.65 km) |
| Big Lake to Seabrook (Maryland) | 967.81 mi (1,557.54 km) |
| Big Lake to Seabrook (Texas) | 1,091.59 mi (1,756.74 km) |
| Big Lake to Seaford (New York) | 1,069.64 mi (1,721.42 km) |
| Big Lake to Seagoville (Texas) | 889.37 mi (1,431.30 km) |
| Big Lake to Seal Beach (California) | 1,514.31 mi (2,437.05 km) |
| Big Lake to Searcy (Arkansas) | 705.75 mi (1,135.80 km) |
| Big Lake to Seaside (California) | 1,573.34 mi (2,532.05 km) |
| Big Lake to SeaTac (Washington) | 1,360.76 mi (2,189.94 km) |
| Big Lake to Seattle (Washington) | 1,361.06 mi (2,190.42 km) |
| Big Lake to Sebastian (Florida) | 1,414.73 mi (2,276.78 km) |
| Big Lake to Sebring (Florida) | 1,407.12 mi (2,264.54 km) |
| Big Lake to Secaucus (New Jersey) | 1,039.04 mi (1,672.17 km) |
