| Big Lake to Santa Rosa (California) | 1,554.22 mi (2,501.28 km) |
| Big Lake to Santaquin (Utah) | 986.72 mi (1,587.96 km) |
| Big Lake to Santee (California) | 1,506.81 mi (2,424.97 km) |
| Big Lake to Sapulpa (Oklahoma) | 656.46 mi (1,056.47 km) |
| Big Lake to Saraland (Alabama) | 1,046.68 mi (1,684.47 km) |
| Big Lake to Sarasota (Florida) | 1,388.15 mi (2,234.01 km) |
| Big Lake to Sarasota Springs (Florida) | 1,391.72 mi (2,239.76 km) |
| Big Lake to Saratoga (California) | 1,560.45 mi (2,511.31 km) |
| Big Lake to Saratoga Springs (New York) | 998.65 mi (1,607.18 km) |
| Big Lake to Saratoga Springs (Utah) | 980.55 mi (1,578.04 km) |
| Big Lake to Sartell (Minnesota) | 30.02 mi (48.31 km) |
| Big Lake to Satellite Beach (Florida) | 1,387.09 mi (2,232.30 km) |
| Big Lake to Sauk Rapids (Minnesota) | 26.63 mi (42.86 km) |
| Big Lake to Sault Ste. Marie (Michigan) | 457.04 mi (735.54 km) |
| Big Lake to Savage (Minnesota) | 44.62 mi (71.80 km) |
