| Denver (Colorado) to Mission Viejo | 824.64 mi (1,327.13 km) |
| Portland (Oregon) to Mission Viejo | 865.52 mi (1,392.92 km) |
| Seattle (Washington) to Mission Viejo | 998.11 mi (1,606.30 km) |
| Dallas (Texas) to Mission Viejo | 1,206.91 mi (1,942.33 km) |
| Houston (Texas) to Mission Viejo | 1,332.61 mi (2,144.63 km) |
| Minneapolis (Minnesota) to Mission Viejo | 1,512.98 mi (2,434.90 km) |
| St. Louis (Missouri) to Mission Viejo | 1,562.43 mi (2,514.48 km) |
| Chicago (Illinois) to Mission Viejo | 1,723.21 mi (2,773.24 km) |
| Atlanta (Georgia) to Mission Viejo | 1,902.23 mi (3,061.35 km) |
| Detroit (Michigan) to Mission Viejo | 1,961.11 mi (3,156.10 km) |
| Tampa (Florida) to Mission Viejo | 2,114.92 mi (3,403.64 km) |
| Washington (District of Columbia) to Mission Viejo | 2,274.55 mi (3,660.53 km) |
| Baltimore (Maryland) to Mission Viejo | 2,294.43 mi (3,692.53 km) |
| Miami (Florida) to Mission Viejo | 2,298.28 mi (3,698.72 km) |
| Philadelphia (Pennsylvania) to Mission Viejo | 2,370.46 mi (3,814.89 km) |
| Brooklyn (New York) to Mission Viejo | 2,430.54 mi (3,911.58 km) |
| New York (New York) to Mission Viejo | 2,431.69 mi (3,913.42 km) |
| Queens (New York) to Mission Viejo | 2,438.17 mi (3,923.85 km) |
| Los Angeles (California) to Mission Viejo | 55.45 mi (89.24 km) |
| San Diego (California) to Mission Viejo | 61.97 mi (99.73 km) |
| Las Vegas (Nevada) to Mission Viejo | 226.23 mi (364.09 km) |
| Boston (Massachusetts) to Mission Viejo | 2,573.66 mi (4,141.90 km) |
| Riverside (California) to Mission Viejo | 27.18 mi (43.73 km) |
| Phoenix (Arizona) to Mission Viejo | 320.32 mi (515.50 km) |
| San Francisco (California) to Mission Viejo | 392.72 mi (632.03 km) |
