| Ashtabula to Southern Pines (North Carolina) | 468.17 mi (753.44 km) |
| Ashtabula to Southfield (Michigan) | 132.61 mi (213.42 km) |
| Ashtabula to Southgate (Michigan) | 125.53 mi (202.03 km) |
| Ashtabula to Southlake (Texas) | 1,085.83 mi (1,747.47 km) |
| Ashtabula to Spanaway (Washington) | 2,058.04 mi (3,312.09 km) |
| Ashtabula to Spanish Fork (Utah) | 1,604.36 mi (2,581.98 km) |
| Ashtabula to Spanish Lake (Missouri) | 539.27 mi (867.88 km) |
| Ashtabula to Spanish Springs (Nevada) | 2,022.43 mi (3,254.79 km) |
| Ashtabula to Sparks (Nevada) | 2,026.51 mi (3,261.35 km) |
| Ashtabula to Spartanburg (South Carolina) | 483.10 mi (777.48 km) |
| Ashtabula to Spearfish (South Dakota) | 1,169.52 mi (1,882.15 km) |
| Ashtabula to Speedway (Indiana) | 319.20 mi (513.70 km) |
| Ashtabula to Spencer (Iowa) | 735.39 mi (1,183.50 km) |
| Ashtabula to Spokane (Washington) | 1,822.78 mi (2,933.47 km) |
| Ashtabula to Spokane Valley (Washington) | 1,813.55 mi (2,918.63 km) |
