| Asheville to Southern Pines (North Carolina) | 179.34 mi (288.62 km) |
| Asheville to Southfield (Michigan) | 478.65 mi (770.30 km) |
| Asheville to Southgate (Michigan) | 459.70 mi (739.82 km) |
| Asheville to Southlake (Texas) | 852.02 mi (1,371.19 km) |
| Asheville to Spanaway (Washington) | 2,188.13 mi (3,521.46 km) |
| Asheville to Spanish Fork (Utah) | 1,610.26 mi (2,591.47 km) |
| Asheville to Spanish Lake (Missouri) | 476.17 mi (766.32 km) |
| Asheville to Spanish Springs (Nevada) | 2,036.31 mi (3,277.12 km) |
| Asheville to Sparks (Nevada) | 2,039.19 mi (3,281.76 km) |
| Asheville to Spartanburg (South Carolina) | 55.96 mi (90.06 km) |
| Asheville to Spearfish (South Dakota) | 1,277.15 mi (2,055.38 km) |
| Asheville to Speedway (Indiana) | 354.81 mi (571.01 km) |
| Asheville to Spencer (Iowa) | 851.09 mi (1,369.69 km) |
| Asheville to Spokane (Washington) | 1,964.37 mi (3,161.35 km) |
| Asheville to Spokane Valley (Washington) | 1,955.29 mi (3,146.73 km) |
