| Appleton to Superior (Colorado) | 4,524.09 mi (7,280.81 km) |
| Appleton to Superior (Wisconsin) | 3,734.20 mi (6,009.61 km) |
| Appleton to Surprise (Arizona) | 5,112.20 mi (8,227.29 km) |
| Appleton to Susanville (California) | 4,985.68 mi (8,023.68 km) |
| Appleton to Sussex (Wisconsin) | 3,762.33 mi (6,054.89 km) |
| Appleton to Suwanee (Georgia) | 4,043.69 mi (6,507.69 km) |
| Appleton to Swansea (Illinois) | 4,049.66 mi (6,517.30 km) |
| Appleton to Sweetwater (Florida) | 4,316.25 mi (6,946.34 km) |
| Appleton to Sweetwater (Texas) | 4,752.87 mi (7,649.01 km) |
| Appleton to Sycamore (Illinois) | 3,833.35 mi (6,169.19 km) |
| Appleton to Sylacauga (Alabama) | 4,174.17 mi (6,717.68 km) |
| Appleton to Sylvania (Ohio) | 3,659.73 mi (5,889.76 km) |
| Appleton to Syosset (New York) | 3,302.24 mi (5,314.44 km) |
| Appleton to Syracuse (New York) | 3,307.76 mi (5,323.32 km) |
| Appleton to Syracuse (Utah) | 4,688.57 mi (7,545.53 km) |
