| Appleton to Southern Pines (North Carolina) | 3,801.53 mi (6,117.97 km) |
| Appleton to Southfield (Michigan) | 3,607.16 mi (5,805.16 km) |
| Appleton to Southgate (Michigan) | 3,617.61 mi (5,821.98 km) |
| Appleton to Southlake (Texas) | 4,605.66 mi (7,412.10 km) |
| Appleton to Spanaway (Washington) | 4,652.70 mi (7,487.80 km) |
| Appleton to Spanish Fork (Utah) | 4,728.49 mi (7,609.77 km) |
| Appleton to Spanish Lake (Missouri) | 4,046.27 mi (6,511.85 km) |
| Appleton to Spanish Springs (Nevada) | 5,001.84 mi (8,049.69 km) |
| Appleton to Sparks (Nevada) | 5,008.00 mi (8,059.60 km) |
| Appleton to Spartanburg (South Carolina) | 3,914.34 mi (6,299.52 km) |
| Appleton to Spearfish (South Dakota) | 4,240.83 mi (6,824.96 km) |
| Appleton to Speedway (Indiana) | 3,847.22 mi (6,191.50 km) |
| Appleton to Spencer (Iowa) | 4,012.42 mi (6,457.37 km) |
| Appleton to Spokane (Washington) | 4,485.37 mi (7,218.51 km) |
| Appleton to Spokane Valley (Washington) | 4,480.10 mi (7,210.02 km) |
