| Appleton to Seymour (Tennessee) | 3,941.31 mi (6,342.92 km) |
| Appleton to Shady Hills (Florida) | 4,268.86 mi (6,870.06 km) |
| Appleton to Shafter (California) | 5,227.97 mi (8,413.60 km) |
| Appleton to Shaker Heights (Ohio) | 3,587.88 mi (5,774.14 km) |
| Appleton to Shakopee (Minnesota) | 3,874.07 mi (6,234.71 km) |
| Appleton to Sharon (Pennsylvania) | 3,558.39 mi (5,726.68 km) |
| Appleton to Sharonville (Ohio) | 3,801.12 mi (6,117.32 km) |
| Appleton to Shasta Lake (California) | 5,021.49 mi (8,081.31 km) |
| Appleton to Shawnee (Kansas) | 4,205.85 mi (6,768.66 km) |
| Appleton to Shawnee (Oklahoma) | 4,473.22 mi (7,198.95 km) |
| Appleton to Sheboygan (Wisconsin) | 3,715.84 mi (5,980.07 km) |
| Appleton to Shelby (North Carolina) | 3,882.23 mi (6,247.85 km) |
| Appleton to Shelbyville (Indiana) | 3,841.73 mi (6,182.67 km) |
| Appleton to Shelbyville (Kentucky) | 3,884.71 mi (6,251.83 km) |
| Appleton to Shelbyville (Tennessee) | 4,065.30 mi (6,542.46 km) |
