| Appleton to Scottsboro (Alabama) | 4,092.19 mi (6,585.74 km) |
| Appleton to Scottsdale (Arizona) | 5,092.15 mi (8,195.02 km) |
| Appleton to Scranton (Pennsylvania) | 3,361.59 mi (5,409.96 km) |
| Appleton to Seabrook (Maryland) | 3,519.24 mi (5,663.66 km) |
| Appleton to Seabrook (Texas) | 4,702.94 mi (7,568.65 km) |
| Appleton to Seaford (New York) | 3,308.47 mi (5,324.47 km) |
| Appleton to Seagoville (Texas) | 4,598.75 mi (7,400.97 km) |
| Appleton to Seal Beach (California) | 5,291.87 mi (8,516.45 km) |
| Appleton to Searcy (Arkansas) | 4,282.15 mi (6,891.45 km) |
| Appleton to Seaside (California) | 5,241.25 mi (8,434.98 km) |
| Appleton to SeaTac (Washington) | 4,629.61 mi (7,450.64 km) |
| Appleton to Seattle (Washington) | 4,620.20 mi (7,435.50 km) |
| Appleton to Sebastian (Florida) | 4,216.89 mi (6,786.43 km) |
| Appleton to Sebring (Florida) | 4,272.20 mi (6,875.45 km) |
| Appleton to Secaucus (New Jersey) | 3,326.24 mi (5,353.06 km) |
