| Appleton to Santa Rosa (California) | 5,160.94 mi (8,305.73 km) |
| Appleton to Santaquin (Utah) | 4,741.07 mi (7,630.01 km) |
| Appleton to Santee (California) | 5,308.62 mi (8,543.40 km) |
| Appleton to Sapulpa (Oklahoma) | 4,407.14 mi (7,092.60 km) |
| Appleton to Saraland (Alabama) | 4,365.73 mi (7,025.96 km) |
| Appleton to Sarasota (Florida) | 4,323.71 mi (6,958.34 km) |
| Appleton to Sarasota Springs (Florida) | 4,322.48 mi (6,956.36 km) |
| Appleton to Saratoga (California) | 5,209.72 mi (8,384.23 km) |
| Appleton to Saratoga Springs (New York) | 3,213.94 mi (5,172.34 km) |
| Appleton to Saratoga Springs (Utah) | 4,724.37 mi (7,603.14 km) |
| Appleton to Sartell (Minnesota) | 3,859.66 mi (6,211.52 km) |
| Appleton to Satellite Beach (Florida) | 4,201.42 mi (6,761.54 km) |
| Appleton to Sauk Rapids (Minnesota) | 3,858.32 mi (6,209.37 km) |
| Appleton to Sault Ste. Marie (Michigan) | 3,467.92 mi (5,581.08 km) |
| Appleton to Savage (Minnesota) | 3,871.01 mi (6,229.78 km) |
