| Appleton to Oswego (Illinois) | 3,835.44 mi (6,172.55 km) |
| Appleton to Oswego (New York) | 3,303.63 mi (5,316.68 km) |
| Appleton to Otsego (Minnesota) | 3,855.55 mi (6,204.90 km) |
| Appleton to Ottawa (Illinois) | 3,869.38 mi (6,227.16 km) |
| Appleton to Ottawa (Kansas) | 4,243.63 mi (6,829.46 km) |
| Appleton to Ottumwa (Iowa) | 4,018.45 mi (6,467.07 km) |
| Appleton to Overland (Missouri) | 4,056.88 mi (6,528.92 km) |
| Appleton to Overland Park (Kansas) | 4,207.93 mi (6,772.01 km) |
| Appleton to Overlea (Maryland) | 3,488.23 mi (5,613.76 km) |
| Appleton to Oviedo (Florida) | 4,200.62 mi (6,760.25 km) |
| Appleton to Owasso (Oklahoma) | 4,382.77 mi (7,053.39 km) |
| Appleton to Owatonna (Minnesota) | 3,898.23 mi (6,273.59 km) |
| Appleton to Owensboro (Kentucky) | 3,979.43 mi (6,404.27 km) |
| Appleton to Owings Mills (Maryland) | 3,496.91 mi (5,627.73 km) |
| Appleton to Owosso (Michigan) | 3,617.90 mi (5,822.46 km) |
