| Appleton to Orangevale (California) | 5,103.49 mi (8,213.28 km) |
| Appleton to Orchards (Washington) | 4,736.33 mi (7,622.38 km) |
| Appleton to Orcutt (California) | 5,300.96 mi (8,531.07 km) |
| Appleton to Oregon (Ohio) | 3,651.84 mi (5,877.07 km) |
| Appleton to Oregon (Wisconsin) | 3,815.17 mi (6,139.92 km) |
| Appleton to Oregon City (Oregon) | 4,757.95 mi (7,657.18 km) |
| Appleton to Orem (Utah) | 4,720.05 mi (7,596.18 km) |
| Appleton to Orinda (California) | 5,178.52 mi (8,334.02 km) |
| Appleton to Orland Park (Illinois) | 3,821.33 mi (6,149.83 km) |
| Appleton to Orlando (Florida) | 4,215.98 mi (6,784.97 km) |
| Appleton to Ormond Beach (Florida) | 4,164.37 mi (6,701.90 km) |
| Appleton to Oro Valley (Arizona) | 5,132.72 mi (8,260.31 km) |
| Appleton to Oroville (California) | 5,066.48 mi (8,153.71 km) |
| Appleton to Oshkosh (Wisconsin) | 3,733.10 mi (6,007.84 km) |
| Appleton to Oskaloosa (Iowa) | 4,013.16 mi (6,458.56 km) |
