| Appleton to Olympia Heights (Florida) | 4,317.57 mi (6,948.45 km) |
| Appleton to Omaha (Nebraska) | 4,137.96 mi (6,659.41 km) |
| Appleton to On Top of the World Designated Place (Florida) | 4,222.28 mi (6,795.11 km) |
| Appleton to Onalaska (Wisconsin) | 3,835.49 mi (6,172.63 km) |
| Appleton to Oneida (New York) | 3,287.38 mi (5,290.53 km) |
| Appleton to Oneonta (New York) | 3,291.35 mi (5,296.92 km) |
| Appleton to Ontario (California) | 5,260.68 mi (8,466.25 km) |
| Appleton to Ontario (Oregon) | 4,675.00 mi (7,523.68 km) |
| Appleton to Opa-locka (Florida) | 4,305.00 mi (6,928.23 km) |
| Appleton to Opelika (Alabama) | 4,165.32 mi (6,703.44 km) |
| Appleton to Opelousas (Louisiana) | 4,538.82 mi (7,304.52 km) |
| Appleton to Orange (California) | 5,281.07 mi (8,499.07 km) |
| Appleton to Orange (Texas) | 4,625.19 mi (7,443.52 km) |
| Appleton to Orange City (Florida) | 4,190.54 mi (6,744.03 km) |
| Appleton to Orangeburg (South Carolina) | 3,943.74 mi (6,346.84 km) |
