| Appleton to Enumclaw (Washington) | 4,635.30 mi (7,459.80 km) |
| Appleton to Ephrata (Pennsylvania) | 3,437.36 mi (5,531.90 km) |
| Appleton to Erie (Colorado) | 4,514.41 mi (7,265.24 km) |
| Appleton to Erie (Pennsylvania) | 3,501.53 mi (5,635.16 km) |
| Appleton to Erlanger (Kentucky) | 3,821.06 mi (6,149.41 km) |
| Appleton to Escanaba (Michigan) | 3,599.88 mi (5,793.45 km) |
| Appleton to Escondido (California) | 5,295.42 mi (8,522.16 km) |
| Appleton to Española (New Mexico) | 4,766.01 mi (7,670.15 km) |
| Appleton to Essex (Maryland) | 3,488.21 mi (5,613.73 km) |
| Appleton to Essex Junction (Vermont) | 3,127.13 mi (5,032.63 km) |
| Appleton to Estelle (Louisiana) | 4,496.70 mi (7,236.74 km) |
| Appleton to Estero (Florida) | 4,340.50 mi (6,985.36 km) |
| Appleton to Euclid (Ohio) | 3,581.35 mi (5,763.63 km) |
| Appleton to Eufaula (Alabama) | 4,194.36 mi (6,750.17 km) |
| Appleton to Eugene (Oregon) | 4,846.29 mi (7,799.36 km) |
