| Appleton to Emeryville (California) | 5,184.35 mi (8,343.40 km) |
| Appleton to Emmaus (Pennsylvania) | 3,394.17 mi (5,462.39 km) |
| Appleton to Emporia (Kansas) | 4,287.65 mi (6,900.31 km) |
| Appleton to Encinitas (California) | 5,306.42 mi (8,539.86 km) |
| Appleton to Endicott (New York) | 3,346.31 mi (5,385.36 km) |
| Appleton to Endwell (New York) | 3,343.75 mi (5,381.25 km) |
| Appleton to Englewood (Colorado) | 4,533.74 mi (7,296.35 km) |
| Appleton to Englewood (Florida) | 4,334.97 mi (6,976.46 km) |
| Appleton to Englewood (New Jersey) | 3,317.60 mi (5,339.16 km) |
| Appleton to Englewood (Ohio) | 3,769.50 mi (6,066.43 km) |
| Appleton to Enid (Oklahoma) | 4,451.82 mi (7,164.51 km) |
| Appleton to Ennis (Texas) | 4,619.35 mi (7,434.12 km) |
| Appleton to Ensley (Florida) | 4,349.51 mi (6,999.87 km) |
| Appleton to Enterprise (Alabama) | 4,251.70 mi (6,842.45 km) |
| Appleton to Enterprise (Nevada) | 5,072.33 mi (8,163.12 km) |
