| Appleton to Eau Claire (Wisconsin) | 3,801.56 mi (6,118.02 km) |
| Appleton to Echelon (New Jersey) | 3,405.47 mi (5,480.57 km) |
| Appleton to Eden (North Carolina) | 3,751.55 mi (6,037.53 km) |
| Appleton to Eden Prairie (Minnesota) | 3,869.88 mi (6,227.97 km) |
| Appleton to Edgewater (Florida) | 4,175.17 mi (6,719.28 km) |
| Appleton to Edgewater (New Jersey) | 3,320.67 mi (5,344.09 km) |
| Appleton to Edgewood (Maryland) | 3,476.91 mi (5,595.55 km) |
| Appleton to Edgewood (Washington) | 4,641.40 mi (7,469.62 km) |
| Appleton to Edina (Minnesota) | 3,864.34 mi (6,219.05 km) |
| Appleton to Edinburg (Texas) | 4,998.20 mi (8,043.83 km) |
| Appleton to Edmond (Oklahoma) | 4,473.48 mi (7,199.37 km) |
| Appleton to Edmonds (Washington) | 4,610.09 mi (7,419.23 km) |
| Appleton to Edwards (Colorado) | 4,590.04 mi (7,386.96 km) |
| Appleton to Edwardsville (Illinois) | 4,037.79 mi (6,498.19 km) |
| Appleton to Effingham (Illinois) | 3,967.39 mi (6,384.89 km) |
