| Appenzell to Southern Pines (North Carolina) | 4,436.02 mi (7,139.08 km) |
| Appenzell to Southfield (Michigan) | 4,267.06 mi (6,867.18 km) |
| Appenzell to Southgate (Michigan) | 4,276.94 mi (6,883.07 km) |
| Appenzell to Southlake (Texas) | 5,267.76 mi (8,477.64 km) |
| Appenzell to Spanaway (Washington) | 5,296.11 mi (8,523.27 km) |
| Appenzell to Spanish Fork (Utah) | 5,395.71 mi (8,683.55 km) |
| Appenzell to Spanish Lake (Missouri) | 4,708.14 mi (7,577.02 km) |
| Appenzell to Spanish Springs (Nevada) | 5,661.17 mi (9,110.78 km) |
| Appenzell to Sparks (Nevada) | 5,667.36 mi (9,120.74 km) |
| Appenzell to Spartanburg (South Carolina) | 4,553.99 mi (7,328.94 km) |
| Appenzell to Spearfish (South Dakota) | 4,909.71 mi (7,901.41 km) |
| Appenzell to Speedway (Indiana) | 4,505.92 mi (7,251.57 km) |
| Appenzell to Spencer (Iowa) | 4,681.87 mi (7,534.73 km) |
| Appenzell to Spokane (Washington) | 5,136.70 mi (8,266.71 km) |
| Appenzell to Spokane Valley (Washington) | 5,131.74 mi (8,258.75 km) |
