| Appenweier to Southern Pines (North Carolina) | 4,341.25 mi (6,986.57 km) |
| Appenweier to Southfield (Michigan) | 4,166.14 mi (6,704.76 km) |
| Appenweier to Southgate (Michigan) | 4,176.18 mi (6,720.92 km) |
| Appenweier to Southlake (Texas) | 5,166.29 mi (8,314.35 km) |
| Appenweier to Spanaway (Washington) | 5,190.20 mi (8,352.82 km) |
| Appenweier to Spanish Fork (Utah) | 5,289.34 mi (8,512.36 km) |
| Appenweier to Spanish Lake (Missouri) | 4,606.70 mi (7,413.76 km) |
| Appenweier to Spanish Springs (Nevada) | 5,554.56 mi (8,939.20 km) |
| Appenweier to Sparks (Nevada) | 5,560.75 mi (8,949.16 km) |
| Appenweier to Spartanburg (South Carolina) | 4,458.11 mi (7,174.64 km) |
| Appenweier to Spearfish (South Dakota) | 4,803.63 mi (7,730.70 km) |
| Appenweier to Speedway (Indiana) | 4,405.37 mi (7,089.75 km) |
| Appenweier to Spencer (Iowa) | 4,577.46 mi (7,366.72 km) |
| Appenweier to Spokane (Washington) | 5,030.33 mi (8,095.54 km) |
| Appenweier to Spokane Valley (Washington) | 5,025.37 mi (8,087.54 km) |
