| Apopka to Southern Pines (North Carolina) | 465.48 mi (749.12 km) |
| Apopka to Southfield (Michigan) | 956.64 mi (1,539.57 km) |
| Apopka to Southgate (Michigan) | 937.67 mi (1,509.04 km) |
| Apopka to Southlake (Texas) | 971.01 mi (1,562.69 km) |
| Apopka to Spanaway (Washington) | 2,526.47 mi (4,065.96 km) |
| Apopka to Spanish Fork (Utah) | 1,876.64 mi (3,020.16 km) |
| Apopka to Spanish Lake (Missouri) | 855.88 mi (1,377.41 km) |
| Apopka to Spanish Springs (Nevada) | 2,287.70 mi (3,681.70 km) |
| Apopka to Sparks (Nevada) | 2,289.43 mi (3,684.48 km) |
| Apopka to Spartanburg (South Carolina) | 431.95 mi (695.15 km) |
| Apopka to Spearfish (South Dakota) | 1,638.74 mi (2,637.30 km) |
| Apopka to Speedway (Indiana) | 812.02 mi (1,306.81 km) |
| Apopka to Spencer (Iowa) | 1,252.25 mi (2,015.31 km) |
| Apopka to Spokane (Washington) | 2,317.41 mi (3,729.50 km) |
| Apopka to Spokane Valley (Washington) | 2,308.70 mi (3,715.50 km) |
