| Ankeny to Enumclaw (Washington) | 1,441.07 mi (2,319.17 km) |
| Ankeny to Ephrata (Pennsylvania) | 913.77 mi (1,470.57 km) |
| Ankeny to Erie (Colorado) | 608.22 mi (978.83 km) |
| Ankeny to Erie (Pennsylvania) | 695.34 mi (1,119.04 km) |
| Ankeny to Erlanger (Kentucky) | 510.12 mi (820.96 km) |
| Ankeny to Escanaba (Michigan) | 427.32 mi (687.70 km) |
| Ankeny to Escondido (California) | 1,411.87 mi (2,272.19 km) |
| Ankeny to Española (New Mexico) | 777.39 mi (1,251.09 km) |
| Ankeny to Essex (Maryland) | 915.11 mi (1,472.73 km) |
| Ankeny to Essex Junction (Vermont) | 1,048.06 mi (1,686.69 km) |
| Ankeny to Estelle (Louisiana) | 844.02 mi (1,358.32 km) |
| Ankeny to Estero (Florida) | 1,251.94 mi (2,014.80 km) |
| Ankeny to Euclid (Ohio) | 623.35 mi (1,003.19 km) |
| Ankeny to Eufaula (Alabama) | 822.94 mi (1,324.39 km) |
| Ankeny to Eugene (Oregon) | 1,494.57 mi (2,405.27 km) |
