| Ankeny to Emeryville (California) | 1,539.47 mi (2,477.54 km) |
| Ankeny to Emmaus (Pennsylvania) | 944.06 mi (1,519.32 km) |
| Ankeny to Emporia (Kansas) | 267.49 mi (430.48 km) |
| Ankeny to Encinitas (California) | 1,424.28 mi (2,292.15 km) |
| Ankeny to Endicott (New York) | 900.58 mi (1,449.34 km) |
| Ankeny to Endwell (New York) | 902.62 mi (1,452.62 km) |
| Ankeny to Englewood (Colorado) | 613.38 mi (987.14 km) |
| Ankeny to Englewood (Florida) | 1,202.33 mi (1,934.96 km) |
| Ankeny to Englewood (New Jersey) | 1,018.18 mi (1,638.61 km) |
| Ankeny to Englewood (Ohio) | 502.73 mi (809.07 km) |
| Ankeny to Enid (Oklahoma) | 433.02 mi (696.89 km) |
| Ankeny to Ennis (Texas) | 670.76 mi (1,079.48 km) |
| Ankeny to Ensley (Florida) | 850.21 mi (1,368.28 km) |
| Ankeny to Enterprise (Alabama) | 836.95 mi (1,346.95 km) |
| Ankeny to Enterprise (Nevada) | 1,224.64 mi (1,970.87 km) |
