| Americus to Enumclaw (Washington) | 2,235.51 mi (3,597.70 km) |
| Americus to Ephrata (Pennsylvania) | 717.15 mi (1,154.15 km) |
| Americus to Erie (Colorado) | 1,282.17 mi (2,063.46 km) |
| Americus to Erie (Pennsylvania) | 730.40 mi (1,175.47 km) |
| Americus to Erlanger (Kentucky) | 479.75 mi (772.08 km) |
| Americus to Escanaba (Michigan) | 957.09 mi (1,540.29 km) |
| Americus to Escondido (California) | 1,905.47 mi (3,066.55 km) |
| Americus to Española (New Mexico) | 1,276.90 mi (2,054.97 km) |
| Americus to Essex (Maryland) | 662.80 mi (1,066.68 km) |
| Americus to Essex Junction (Vermont) | 1,046.23 mi (1,683.75 km) |
| Americus to Estelle (Louisiana) | 380.68 mi (612.65 km) |
| Americus to Estero (Florida) | 416.65 mi (670.53 km) |
| Americus to Euclid (Ohio) | 674.25 mi (1,085.10 km) |
| Americus to Eufaula (Alabama) | 55.41 mi (89.17 km) |
| Americus to Eugene (Oregon) | 2,246.82 mi (3,615.90 km) |
