| American Canyon to Southern Pines (North Carolina) | 2,362.32 mi (3,801.79 km) |
| American Canyon to Southfield (Michigan) | 2,057.13 mi (3,310.63 km) |
| American Canyon to Southgate (Michigan) | 2,061.64 mi (3,317.88 km) |
| American Canyon to Southlake (Texas) | 1,451.64 mi (2,336.19 km) |
| American Canyon to Spanaway (Washington) | 616.25 mi (991.76 km) |
| American Canyon to Spanish Fork (Utah) | 583.99 mi (939.84 km) |
| American Canyon to Spanish Lake (Missouri) | 1,725.04 mi (2,776.18 km) |
| American Canyon to Spanish Springs (Nevada) | 172.57 mi (277.73 km) |
| American Canyon to Sparks (Nevada) | 167.25 mi (269.16 km) |
| American Canyon to Spartanburg (South Carolina) | 2,231.89 mi (3,591.87 km) |
| American Canyon to Spearfish (South Dakota) | 1,048.37 mi (1,687.19 km) |
| American Canyon to Speedway (Indiana) | 1,924.12 mi (3,096.57 km) |
| American Canyon to Spencer (Iowa) | 1,454.53 mi (2,340.85 km) |
| American Canyon to Spokane (Washington) | 699.15 mi (1,125.17 km) |
| American Canyon to Spokane Valley (Washington) | 702.40 mi (1,130.40 km) |
