| Alpena to Superior (Colorado) | 1,157.75 mi (1,863.23 km) |
| Alpena to Superior (Wisconsin) | 430.21 mi (692.36 km) |
| Alpena to Surprise (Arizona) | 1,724.95 mi (2,776.05 km) |
| Alpena to Susanville (California) | 1,896.16 mi (3,051.58 km) |
| Alpena to Sussex (Wisconsin) | 272.43 mi (438.44 km) |
| Alpena to Suwanee (Georgia) | 762.36 mi (1,226.90 km) |
| Alpena to Swansea (Illinois) | 562.40 mi (905.10 km) |
| Alpena to Sweetwater (Florida) | 1,344.04 mi (2,163.02 km) |
| Alpena to Sweetwater (Texas) | 1,257.66 mi (2,024.01 km) |
| Alpena to Sycamore (Illinois) | 337.78 mi (543.60 km) |
| Alpena to Sylacauga (Alabama) | 835.57 mi (1,344.72 km) |
| Alpena to Sylvania (Ohio) | 232.82 mi (374.69 km) |
| Alpena to Syosset (New York) | 581.81 mi (936.33 km) |
| Alpena to Syracuse (New York) | 388.40 mi (625.08 km) |
| Alpena to Syracuse (Utah) | 1,462.85 mi (2,354.22 km) |
