| Alpena to Storm Lake (Iowa) | 608.65 mi (979.52 km) |
| Alpena to Storrs (Connecticut) | 604.31 mi (972.55 km) |
| Alpena to Stoughton (Wisconsin) | 323.42 mi (520.49 km) |
| Alpena to Stow (Ohio) | 287.64 mi (462.90 km) |
| Alpena to Streamwood (Illinois) | 317.38 mi (510.77 km) |
| Alpena to Streator (Illinois) | 385.05 mi (619.68 km) |
| Alpena to Streetsboro (Ohio) | 285.16 mi (458.93 km) |
| Alpena to Strongsville (Ohio) | 272.20 mi (438.07 km) |
| Alpena to Stuart (Florida) | 1,247.79 mi (2,008.13 km) |
| Alpena to Stuarts Draft (Virginia) | 537.84 mi (865.57 km) |
| Alpena to Sturgis (Michigan) | 247.06 mi (397.61 km) |
| Alpena to Suamico (Wisconsin) | 228.67 mi (368.01 km) |
| Alpena to Sudley (Virginia) | 530.70 mi (854.08 km) |
| Alpena to Suffern (New York) | 542.59 mi (873.21 km) |
| Alpena to Suffolk (Virginia) | 678.63 mi (1,092.14 km) |
