| Alpena to Southern Pines (North Carolina) | 715.00 mi (1,150.68 km) |
| Alpena to Southfield (Michigan) | 179.69 mi (289.19 km) |
| Alpena to Southgate (Michigan) | 198.60 mi (319.61 km) |
| Alpena to Southlake (Texas) | 1,111.70 mi (1,789.12 km) |
| Alpena to Spanaway (Washington) | 1,853.94 mi (2,983.63 km) |
| Alpena to Spanish Fork (Utah) | 1,466.79 mi (2,360.57 km) |
| Alpena to Spanish Lake (Missouri) | 556.00 mi (894.80 km) |
| Alpena to Spanish Springs (Nevada) | 1,870.65 mi (3,010.52 km) |
| Alpena to Sparks (Nevada) | 1,875.23 mi (3,017.89 km) |
| Alpena to Spartanburg (South Carolina) | 704.44 mi (1,133.69 km) |
| Alpena to Spearfish (South Dakota) | 997.40 mi (1,605.17 km) |
| Alpena to Speedway (Indiana) | 391.86 mi (630.64 km) |
| Alpena to Spencer (Iowa) | 595.56 mi (958.46 km) |
| Alpena to Spokane (Washington) | 1,617.29 mi (2,602.78 km) |
| Alpena to Spokane Valley (Washington) | 1,608.15 mi (2,588.07 km) |
