| Alpena to Olympia Heights (Florida) | 1,348.04 mi (2,169.47 km) |
| Alpena to Omaha (Nebraska) | 687.03 mi (1,105.67 km) |
| Alpena to On Top of the World Designated Place (Florida) | 1,105.09 mi (1,778.48 km) |
| Alpena to Onalaska (Wisconsin) | 391.40 mi (629.90 km) |
| Alpena to Oneida (New York) | 409.80 mi (659.51 km) |
| Alpena to Oneonta (New York) | 455.04 mi (732.31 km) |
| Alpena to Ontario (California) | 1,955.03 mi (3,146.31 km) |
| Alpena to Ontario (Oregon) | 1,640.98 mi (2,640.91 km) |
| Alpena to Opa-locka (Florida) | 1,336.59 mi (2,151.04 km) |
| Alpena to Opelika (Alabama) | 863.87 mi (1,390.27 km) |
| Alpena to Opelousas (Louisiana) | 1,108.84 mi (1,784.50 km) |
| Alpena to Orange (California) | 1,974.29 mi (3,177.31 km) |
| Alpena to Orange (Texas) | 1,175.16 mi (1,891.23 km) |
| Alpena to Orange City (Florida) | 1,121.30 mi (1,804.56 km) |
| Alpena to Orangeburg (South Carolina) | 811.81 mi (1,306.48 km) |
