| Alpena to Enumclaw (Washington) | 1,832.63 mi (2,949.33 km) |
| Alpena to Ephrata (Pennsylvania) | 500.09 mi (804.82 km) |
| Alpena to Erie (Colorado) | 1,148.95 mi (1,849.06 km) |
| Alpena to Erie (Pennsylvania) | 264.78 mi (426.12 km) |
| Alpena to Erlanger (Kentucky) | 423.01 mi (680.78 km) |
| Alpena to Escanaba (Michigan) | 183.03 mi (294.56 km) |
| Alpena to Escondido (California) | 1,964.47 mi (3,161.52 km) |
| Alpena to Española (New Mexico) | 1,336.87 mi (2,151.48 km) |
| Alpena to Essex (Maryland) | 535.58 mi (861.93 km) |
| Alpena to Essex Junction (Vermont) | 507.67 mi (817.01 km) |
| Alpena to Estelle (Louisiana) | 1,112.87 mi (1,790.99 km) |
| Alpena to Estero (Florida) | 1,291.56 mi (2,078.57 km) |
| Alpena to Euclid (Ohio) | 259.33 mi (417.35 km) |
| Alpena to Eufaula (Alabama) | 914.16 mi (1,471.20 km) |
| Alpena to Eugene (Oregon) | 1,934.68 mi (3,113.57 km) |
