| Alpena to Emeryville (California) | 2,051.95 mi (3,302.30 km) |
| Alpena to Emmaus (Pennsylvania) | 509.92 mi (820.64 km) |
| Alpena to Emporia (Kansas) | 801.45 mi (1,289.81 km) |
| Alpena to Encinitas (California) | 1,976.82 mi (3,181.38 km) |
| Alpena to Endicott (New York) | 422.32 mi (679.66 km) |
| Alpena to Endwell (New York) | 423.42 mi (681.43 km) |
| Alpena to Englewood (Colorado) | 1,158.39 mi (1,864.25 km) |
| Alpena to Englewood (Florida) | 1,252.19 mi (2,015.21 km) |
| Alpena to Englewood (New Jersey) | 558.44 mi (898.72 km) |
| Alpena to Englewood (Ohio) | 362.65 mi (583.63 km) |
| Alpena to Enid (Oklahoma) | 961.50 mi (1,547.39 km) |
| Alpena to Ennis (Texas) | 1,129.20 mi (1,817.27 km) |
| Alpena to Ensley (Florida) | 1,026.40 mi (1,651.84 km) |
| Alpena to Enterprise (Alabama) | 958.61 mi (1,542.74 km) |
| Alpena to Enterprise (Nevada) | 1,768.85 mi (2,846.69 km) |
