| Aliso Viejo to Storm Lake (Iowa) | 1,369.82 mi (2,204.51 km) |
| Aliso Viejo to Storrs (Connecticut) | 2,519.99 mi (4,055.53 km) |
| Aliso Viejo to Stoughton (Wisconsin) | 1,665.79 mi (2,680.83 km) |
| Aliso Viejo to Stow (Ohio) | 2,044.65 mi (3,290.54 km) |
| Aliso Viejo to Streamwood (Illinois) | 1,705.22 mi (2,744.29 km) |
| Aliso Viejo to Streator (Illinois) | 1,661.69 mi (2,674.24 km) |
| Aliso Viejo to Streetsboro (Ohio) | 2,049.49 mi (3,298.33 km) |
| Aliso Viejo to Strongsville (Ohio) | 2,024.60 mi (3,258.27 km) |
| Aliso Viejo to Stuart (Florida) | 2,264.60 mi (3,644.53 km) |
| Aliso Viejo to Stuarts Draft (Virginia) | 2,174.22 mi (3,499.06 km) |
| Aliso Viejo to Sturgis (Michigan) | 1,843.12 mi (2,966.22 km) |
| Aliso Viejo to Suamico (Wisconsin) | 1,751.04 mi (2,818.03 km) |
| Aliso Viejo to Sudley (Virginia) | 2,253.99 mi (3,627.45 km) |
| Aliso Viejo to Suffern (New York) | 2,423.90 mi (3,900.89 km) |
| Aliso Viejo to Suffolk (Virginia) | 2,313.94 mi (3,723.93 km) |
