| Aliso Viejo to Southern Pines (North Carolina) | 2,174.58 mi (3,499.64 km) |
| Aliso Viejo to Southfield (Michigan) | 1,958.58 mi (3,152.03 km) |
| Aliso Viejo to Southgate (Michigan) | 1,959.24 mi (3,153.09 km) |
| Aliso Viejo to Southlake (Texas) | 1,187.67 mi (1,911.37 km) |
| Aliso Viejo to Spanaway (Washington) | 965.74 mi (1,554.21 km) |
| Aliso Viejo to Spanish Fork (Utah) | 562.66 mi (905.51 km) |
| Aliso Viejo to Spanish Lake (Missouri) | 1,569.99 mi (2,526.65 km) |
| Aliso Viejo to Spanish Springs (Nevada) | 433.46 mi (697.58 km) |
| Aliso Viejo to Sparks (Nevada) | 428.56 mi (689.71 km) |
| Aliso Viejo to Spartanburg (South Carolina) | 2,035.79 mi (3,276.29 km) |
| Aliso Viejo to Spearfish (South Dakota) | 1,058.24 mi (1,703.08 km) |
| Aliso Viejo to Speedway (Indiana) | 1,786.36 mi (2,874.87 km) |
| Aliso Viejo to Spencer (Iowa) | 1,383.94 mi (2,227.23 km) |
| Aliso Viejo to Spokane (Washington) | 973.50 mi (1,566.70 km) |
| Aliso Viejo to Spokane Valley (Washington) | 973.41 mi (1,566.55 km) |
